Helicase–primase inhibitors: a new approach to combat herpes simplex virus and varicella zoster virus

<p>This chapter (no. 6) contains sections titled:1. Introduction2. The Role of Helicase Primase in the Replication of HSV3. Selective Inhibitors of Helicase Primase as Antiherpesvirus Antivirals4. HPIs are Effective in Cell Culture and In Vivo5. Effects of HPIs on the Establishment and Reactivation from Latency6. HPIs: The Biochemical Basis for the Proposed Mechanism of Action7. HSV Acquired Resistance to HPIs8. Patterns of Cross-Resistance9. Further Insight into Mode of HPI Interaction with the HSV HP Complex from the Study of Resistance Mutations10. The Frequency and Origin of HPI-Resistance Mutations11. UL5 Lys356Asn: a Mutation Conferring High Resistance to HPI12. The Origin of Resistance Mutations at High Frequency13. Conclusions14. References</p>