Chromatographic enantioresolution and stereochemical characterization of synthetic cannabinoid receptor agonists with Whelk-O®1 chiral stationary phases under mass spectrometry compatible reversed-phase conditions: A study case with seized samples
journal contribution
posted on 2025-03-04, 12:15 authored by Ina Varfaj, Michele Protti, Alessandro Di Michele, Jose Gonzalez-RodriguezJose Gonzalez-Rodriguez, Andrea Carotti, Roccaldo Sardella, Laura MercoliniHighlights
- •Synthetic cannabinoid receptor agonists were enantioseparated with Whelk-O®1 CSPs.
- •Efficient enantioseparations were obtained under reversed-phase conditions.
- •The developed HPLC method was compatible to MS detection.
- •The ICCA concept was useful to appraise the enantiopurity of the studied compounds.
- •Coupling ECD analysis to in silico simulations allowed to establish the EEO.
History
School affiliated with
- School of Chemistry (Research Outputs)
Publication Title
Analytica Chimica ActaVolume
1317Pages/Article Number
342901Publisher
ElsevierExternal DOI
ISSN
0003-2670eISSN
1873-4324Date Submitted
2024-01-09Date Accepted
2024-06-21Date of First Publication
2024-06-22Date of Final Publication
2024-08-15Open Access Status
- Open Access
Date Document First Uploaded
2024-11-25Will your conference paper be published in proceedings?
- N/A
