Enforcing Ostwald's rule of stages: isolation of paracetamol forms III and II

<p>We have been able to isolate and study the polymorphic form III of paracetamol using a speciallydesigned methodology. Our work represents the first report of a reproducible, reliableroute to form III. This has been an outstanding problem for over quarter of a century. Ourmethod may be applicable to the isolation of metastable polymorphs of other compounds.</p>