Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation
Version 2 2024-03-12, 12:02
Version 1 2023-10-18, 07:40
journal contribution
posted on 2024-03-12, 12:02 authored by Ishwar Singh, Joseph S. Vyle, Frances Heaney<p>Solid-phase oligonucleotide conjugation by nitrile oxide-alkyne click cycloaddition chemistry has been successfully demonstrated; the reaction, compatible with all nucleobases, requires no metal catalyst and proceeds under physiological conditions.</p>
History
School affiliated with
- School of Pharmacy (Research Outputs)
