Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

Cousins, Alex R. O.; Ritson, Dougal; Sharma, Pallavi; Stevens, Malcolm F. G.; Moses, John E.; Searle, Mark S.

Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

https://hdl.handle.net/10779/lincoln.24338872

journal contribution

posted on 2024-03-12, 13:04 authored by Alex R. O. Cousins, Dougal Ritson, Pallavi Sharma, Malcolm F. G. Stevens, John E. Moses, Mark S. Searle

<p>Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based ‘click’ ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for selectivity in binding at the interface between tandem quadruplex motifs.</p>

Funding

Worldwide Cancer Research (Formerly known as AICR)

History

School affiliated with

School of Chemistry (Research Outputs)

Publication Title

Chemical Communications

Volume

50

Pages/Article Number

15202-15205

Publisher

Royal Society of Chemistry

External DOI

https://doi.org/10.1039/C4CC07487D

ISSN

1359-7345

eISSN

1364-548X

Date Submitted

2014-11-11

Date Accepted

2014-10-17

Date of First Publication

2014-10-23

Date of Final Publication

2014-10-23

Date Document First Uploaded

2014-11-11

ePrints ID

15968

Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

Funding

Worldwide Cancer Research (Formerly known as AICR)

History

School affiliated with

Publication Title

Volume

Pages/Article Number

Publisher

External DOI

ISSN

eISSN

Date Submitted

Date Accepted

Date of First Publication

Date of Final Publication

Date Document First Uploaded

ePrints ID

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