The 4‘I’s for a holistic musculoskeletal rehabilitation approach following hematopoietic stem cell transplantation

 This extensive study off ers a holistic approach to musculoskeletal rehabilitation strategies for individuals undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), with a particular focus on musculoskeletal manifestations. Merging scientific insights with clinical aspects, the work navigates through pivotal components that covers global functional evaluation, patient-oriented exercise rehabilitation, knowledge of drug-drug interactions, and understanding patients' and caregivers' perspectives on quality of life, and applications of the HSCT Hexagon framework. Real-world case studies were judiciously incorporated, off ering substantive recommendations for optimizing patient care throughout the allo-HSCT trajectory. In summary, this thorough study aims to supply the healthcare providers employed in HCT rehabilitation with profound understanding and detailed insights into the problems of rehabilitation in this unique context. Moreover, it highlights the areas of improvement in the delivery of post-HCT services which can be used by both policymakers and clinicians, aiming for improvement of appropriate services and management of the patients.